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KMID : 0371019880210020340
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Journal of Preventive Medicine and Public Health
1988 Volume.21 No. 2 p.340 ~ p.350
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Effect of Dietary Calcium, Casein, and Suet on the Accumulation of Cadmium in Mice
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Abstract
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This study was carried out to clarify the effect of dietary calcium, casein, and suet on the accumulation
of cadmium in mice. It was performed for 30 days, from April 11 to May 10 1988. 90 mice were divided
into 4 experimental groups and control group with 6 mice each dietary group; and measured survival
rate, body weight, and weight ratio of organ to body. The contents of cadmium in liver, kidney, spleen,
muscle and skin with hair, and feces were analyzed by atomic absorption spectrophotometer after sacrifice
by anesthesia.
After 30 days, the survival rate of control group was 100%, but 66.7% in group IV(basal diet+Cd+Ca)
with single dose of 100/ig cadmium and with free-intake of water containing 50ppm cadmium, and group
V(basal diet+Cd+suet) with free-intake of water containing 50ppm cadmium.
The rate of weight gain in the case of single dose of 100,ug cadmium was highest in group IV as
42.3%n and lowest in group V as 26.0%, whereas in the cases of free intake group IV was highest as
24.0% and group II(basal diet+Cd) was lowest as 11.6%.
The body weight, in the case of single dose of 100,ug cadmium showed no increase until 5th day
after acute poisoning. But in the case of free intake group, it showed very slight increase through all
the breeding period. The weight ratio of organ to body were lowest in the liver of group II in both
occasions.
The most of cadmium adminstered. were excreted through feces within 2 days after single dose of,
100,ug cadmium.
The contents of cadmium in each group were significantly higher than those of control group. In the
liver, kidney, spleen and muscle, group II showed the highest level in both occasions of 100,ug single dose and free intake of water containing 50ppm cadmium.
In the skin with hair, group II of the occasion with single dose of 100,ug and group V with free intake showed the highest level. And the contents of cadmium in tissue were markedly higher in the occasion of free intake of water containing 50ppm cadmium.
From the above results I would conclude that the addition of casein and calcium are effective in the inhibition of intesitnal absorption of cadmium esp. by calcium.
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KEYWORD
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